North ShoreHYPERBARICS

Research and evidence

The studies behind what we treat.

We treat the conditions where the evidence holds up and Medicare agrees. Here is that evidence, in plain words or clinical detail, with a link to the source for each one.

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What a course of treatment looks like, from people who have been through it

These are independent videos from hospitals and news programs, not filmed at our clinics. They show the same kind of treatment for the same conditions.

Hyperbaric oxygen enhances wound healing

Ohio State Wexner Medical Center

Independent third-party video, not filmed at our clinics. Watch on YouTube

HBOT treatment for wounds: a patient's experience

Community Health Network

Independent third-party video, not filmed at our clinics. Watch on YouTube

Hyperbaric oxygen for delayed radiation injury

Dr. Gregory Weir, Vascular and Hyperbaric Medicine

Independent third-party video, not filmed at our clinics. Watch on YouTube

Cancer survivor's recovery through hyperbaric oxygen

WMAR-2 News, Baltimore

Independent third-party video, not filmed at our clinics. Watch on YouTube

Study library

The published evidence, condition by condition

Hearing and visionClinical guideline

Clinical practice guideline: sudden hearing loss (update)

Chandrasekhar SS, Tsai Do BS, Schwartz SR, et al. (AAO-HNS). Otolaryngology, Head and Neck Surgery, 2019.

The ear, nose and throat specialty guideline lists oxygen sessions plus steroids as an option within the first two weeks of sudden hearing loss, and as a rescue option up to one month.

Find on PubMed →
Infection and boneClinical guideline

Hyperbaric Oxygen Therapy Indications, 14th edition

Undersea and Hyperbaric Medical Society (Moon RE, ed.). UHMS, 2019.

The professional society's reference lists every condition where the evidence supports oxygen under pressure, including chronic bone infection that has not cleared with surgery and antibiotics.

Find on PubMed →
After radiation treatmentCochrane review

Hyperbaric oxygen therapy for late radiation tissue injury

Bennett MH, Feldmeier J, Hampson NB, et al.. Cochrane Database of Systematic Reviews, 2016.

For tissue damaged by radiation in the head, neck and bowel, oxygen sessions improved healing in the randomized trials the review could find.

Find on PubMed →
Wounds that will not healCochrane review

Hyperbaric oxygen therapy for chronic wounds

Kranke P, Bennett MH, et al.. Cochrane Database of Systematic Reviews, 2015.

Across the randomized trials, people with diabetic foot ulcers who added oxygen sessions were more likely to have the wound closed in the short term than people on wound care alone.

Find on PubMed →
Hearing and visionCochrane review

Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss and tinnitus

Bennett MH, Kertesz T, Perleth M, et al.. Cochrane Database of Systematic Reviews, 2012.

When started within two weeks of sudden hearing loss, oxygen sessions improved hearing in the trials reviewed. Started late, the benefit is unclear.

Find on PubMed →
Hearing and visionSystematic review

Hyperbaric oxygen therapy for central retinal artery occlusion

Murphy-Lavoie H, Butler F, Hagan C. Undersea and Hyperbaric Medicine, 2012.

When the main artery to the retina blocks, oxygen under pressure can keep the retina alive while the blockage clears. The sooner it starts, the better the chance of saving vision.

Find on PubMed →
Wounds that will not healRandomized trial

Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes (HODFU)

Londahl M, Katzman P, Nilsson A, Hammarlund C. Diabetes Care, 2010.

In a placebo-controlled trial, about half of the patients who had real oxygen sessions had their foot ulcer fully healed a year later, compared with under a third of those who breathed ordinary air in the chamber.

Find on PubMed →
After radiation treatmentRandomized trial

Hyperbaric oxygen treatment of chronic refractory radiation proctitis: a randomized and controlled double-blind crossover trial

Clarke RE, Tenorio LM, Hussey JR, et al.. International Journal of Radiation Oncology, Biology, Physics, 2008.

People with rectal bleeding and pain years after pelvic radiation improved more often with oxygen sessions than with sham sessions.

Find on PubMed →
Infection and boneRandomized trial

Hyperbaric oxygen therapy in the management of crush injuries: a randomized double-blind placebo-controlled clinical trial

Bouachour G, Cronier P, Gouello JP, et al.. Journal of Trauma, 1996.

After serious crush injuries to a limb, patients who had oxygen sessions healed more completely and needed fewer repeat surgeries than those who had placebo sessions.

Find on PubMed →
Infection and boneClinical series

Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the need for debridements

Riseman JA, Zamboni WA, Curtis A, et al.. Surgery, 1990.

In a surgical series of flesh-eating infections, adding oxygen sessions to surgery and antibiotics was linked with fewer deaths and fewer repeat operations.

Find on PubMed →
After radiation treatmentRandomized trial

Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin

Marx RE, Johnson RP, Kline SN. Journal of the American Dental Association, 1985.

Patients who had oxygen sessions before and after tooth extractions in a radiated jaw were far less likely to develop bone breakdown than patients given antibiotics alone.

Find on PubMed →
Wounds that will not healRandomized trial

Influence of hyperbaric oxygen on the survival of split skin grafts

Perrins DJ. The Lancet, 1967.

An early controlled trial found that skin grafts were more likely to take when patients had oxygen sessions in the days after surgery.

Find on PubMed →

Showing 12 of 12. Summaries follow the published papers and are not claims about results at our clinics.

Physician's hands reviewing medical records at a desk by a window
Every condition we treat is on the approved list. Bring your records and we check.

Where to check for yourself

UHMS

Undersea and Hyperbaric Medical Society

The professional body for hyperbaric medicine. Publishes the approved indications list and treatment protocols.

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Medicare NCD 20.29

Centers for Medicare and Medicaid Services

The national coverage determination that lists the conditions Medicare pays for. Our approved list is this list.

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PubMed

National Library of Medicine

The index of peer-reviewed medical research. Every study card on this page links to a search here.

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Start here

Questions about the evidence for your condition?

Call and ask for the clinical team. We will tell you what the research shows for your situation, and if oxygen is not the right tool, we say so.

Please do not include medical details here. We will ask what we need by phone.

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